Advances in Heterocyclic Chemistry, Vol. 22 by A. R. Katritzky, A. J. Boulton

By A. R. Katritzky, A. J. Boulton

EDITED via A.R. KATRITZKY AND A.J. BOULTON-ILLUSTRATED WITH GRAPHS AND DIAGRAMS

Show description

Read or Download Advances in Heterocyclic Chemistry, Vol. 22 PDF

Best general & reference books

Molecular Vib-rotors: The Theory and Interpretation of High Resolution Infrared Spectra

Vii + 324 pages together with index, easy conception of resolving the rotational constitution of vibrational bands of lighter and reasonably heavier molecules, bw charts and tables

Advances in Heterocyclic Chemistry, Vol. 22

EDITED by means of A. R. KATRITZKY AND A. J. BOULTON-ILLUSTRATED WITH GRAPHS AND DIAGRAMS

Turning Points in Solid-State, Materials and Surface Science: A Book in Celebration of the Life and Work of Sir John Meurig Thomas , 1st Edition

The clinical exploration of sturdy fabrics represents the most vital, interesting and worthwhile parts of medical endeavour at the moment, not just from the point of view of advancing basic realizing but in addition from the commercial point of view, given the sizeable range of purposes of stable fabrics around the complete variety of business sectors.

Additional info for Advances in Heterocyclic Chemistry, Vol. 22

Example text

54, 1977 (1932). 241 J. E. A. Otterstedt and R. Pater, J. Heterocycl. Chem. 9,225 (1972). 239 240 32 LINDSAY A. SUMMERS [Sec. A (42) to 4,7-bis-2'-cyanoethyl- 1,2,3,4,7,8,9,10-octah ydro- 1,10-dioxo-4,7phenanthroline (43) with aluminum chloride and hydrochloric acid in c h l o r o b e n ~ e n eThe . ~ ~ ~structure was confirmed spectroscopically and by reaction with hydrazine, which gave the tetraazapyrene derivative (44). '~ IV. General Reactions A. REDUCTION 1. IJO-Phenanthroline The reduction of 1,lO-phenanthroline (4) occurs preferentially in the pyridine rings.

F. Elslager and F. H. Tendick, J. Med. Pharrn. Chem. 5,546 (1962). 24 LINDSAY A. SUMMERS [Sec. D C. 12 It was obtained pure in low yield (-4%) along with 2,8-phenanthroline (- 35%). 1,g-Phenanthroline was subsequently obtained in 34% yield by a Skraup synthesis from 8aminoisoquinoline. l 5 This reaction has been used by others. l B 1 D. 182 The original synthesis of 1,lOphenanthr~line~ by a double Skraup reaction on o-phenylenediamine using glycerol and sulfuric acid in the presence of an oxidizing agent continues to attract attention, and various improvements in reaction I** J.

C. Evans, and E. H. Godden, J. Chem. Soc. B, 149 (1970). Z75 J. Mlochowski, Rocz. Chem. 48,2145(1974). 272 38 LINDSAY A. SUMMERS [Sec. C 3. 1 ,I 0-Phenanthroline Reports of further studies of the nitration of 1,lO-phenanthroline have appeared. 252 A much milder route to 5-nitro- 1,lO-phenanthroline involves nitration of the tris-phenanthroline complex of cobalt(II1) which is readily nitrated in concentrated sulfuric acid at 80". 252In this way 3-nitro- 1,lO-phenanthroline was obtained in very low yield.

Download PDF sample

Rated 4.82 of 5 – based on 11 votes