By Bernard M. E. Moret (auth.), Aaron Darling, Jens Stoye (eds.)
This booklet constitutes the refereed court cases of the thirteenth foreign Workshop on Algorithms in Bioinformatics, WABI 2013, held in Sophia Antipolis, France, in September 2013. WABI 2013 is considered one of seven workshops which, besides the ecu Symposium on Algorithms (ESA), represent the ALGO annual assembly and highlights study in algorithmic paintings for bioinformatics, computational biology and platforms biology. The objective is to give contemporary learn effects, together with major work-in-progress, and to spot and discover instructions of destiny study. The 27 complete papers provided have been rigorously reviewed and chosen from sixty one submissions. The papers disguise all points of algorithms in bioinformatics, computational biology and platforms biology.
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Extra resources for Algorithms in Bioinformatics: 13th International Workshop, WABI 2013, Sophia Antipolis, France, September 2-4, 2013. Proceedings
We note that for k = 1 we have L(f ) = N (f ), thus in this case the MKL problem is equivalent to the minimum directed Steiner tree problem. The parameter α balances between two types of solutions: (1) A subnetwork with minimum number of labels (α = 1), which is equivalent to the union of independent Steiner trees of each of the experiments. (2) A subnetwork with minimum number of edges (α = 0), which is simply a Steiner tree that spans the union of all sets of terminals. However, general instances of MKL where α = 0, 1 can be solved neither by combining the independent Steiner trees of each of the experiments nor by constructing a single Steiner tree over all terminals.
Nucleic Acids Res. 28, 235–242 (2000) 2. : Protein structure comparison using representation by line segment sequences. In: Pac. Symp. , pp. 25–40 (1996) 3. : SARFing the PDB. Protein Eng. 9(9), 727–732 (1996) 4. : Structural alignment of large-size proteins via lagrangian relaxation. In: RECOMB 2002: Proceedings of the Sixth Annual International Conference on Computational Biology, pp. 100–108. ACM, New York (2002) 5. : Proust: a comparison method of threedimensional structure of proteins using indexing techniques.
Matt: local ﬂexibility aids protein multiple structure alignment. il 2 Dept. of Cell Research and Immunology, Tel Aviv University, Tel Aviv 69978, Israel Biotechnology Institute Thurgau, University of Konstanz, Unterseestrasse 47, 8280 Kreuzlingen, Switzerland Abstract. The sheer amounts of biological data that are generated in recent years have driven the development of network analysis tools to facilitate the interpretation and representation of these data. A fundamental challenge in this domain is the reconstruction of a proteinprotein subnetwork that underlies a process of interest from a genomewide screen of associated genes.