Androgenetic Alopecia: Modern Concepts of Pathogenesis and by Masumi Inaba M.D., Yoshikata Inaba M.D. (auth.)

By Masumi Inaba M.D., Yoshikata Inaba M.D. (auth.)

The authors have perfected a thick-tissue training strategy for looking at hair at numerous phases of development, and their findings problem the at present held three-stage universal hair cycle. they've got recommend a brand new speculation, the four-stage crucial hair cycle, that comes with their discovery that stem cells can be found within the isthmal component of the sebaceous gland. the basic hair cycle is then used to study the standards contributing to the method of androgenetic alopecia, or untimely balding, because it is usually known as. this can be through an evidence of a few common measures for the prevention of androgenetic alopecia and an outline of the remedies on hand.

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High skin lipid levels by age correspond to high levels of hair growth. ---.... 6. 5 a AGE:6-12 15-19 20-29 30-39 40-49 50-69 Over 70 11 10 .. .... .. 9 ' B ' Males .......... ~ 7 '. '-- Females 4 3 b No. 01 Patients • Age 10 15 20 25 30 35 40 L----L50 45 Sebaceous gland activity tends to remain stable for several decades of adult life, and is generally higher in men than in women. Sebum production in women, however, drops significantly in the age bracket of 50-59 years (Cunliffe and Cotterill197 5; Pochi and Strauss 1965; Pochi et al.

When matrix formation is tation depends on the content of melanin gran- complete, the hair follicle is typically bulbous and ules. Melanocytes sited among the germinative ceases further descent. The new hair begins to ascells in the hair follicle produce the melanin-bear- ce nd toward the skin surface alone. The formation ing melanosomes. These melanosomes consist of a of keratinocytes in the germinal layer occurs in structural matrix and a functional melanin-syn- parallel to the formation of melanocytes (Figs.

5 a AGE:6-12 15-19 20-29 30-39 40-49 50-69 Over 70 11 10 .. .... .. 9 ' B ' Males .......... ~ 7 '. '-- Females 4 3 b No. 01 Patients • Age 10 15 20 25 30 35 40 L----L50 45 Sebaceous gland activity tends to remain stable for several decades of adult life, and is generally higher in men than in women. Sebum production in women, however, drops significantly in the age bracket of 50-59 years (Cunliffe and Cotterill197 5; Pochi and Strauss 1965; Pochi et al. 1979). As mentioned above, the authors' findings indica te that sebaceous gland function is clearly and closely related to hair formation.

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