Bone and Mineral Research. A Regular Survey of Developments by Johan N.M. Heersche and J. A. Kanis (Eds.)

By Johan N.M. Heersche and J. A. Kanis (Eds.)

The purpose in placing jointly this seventh quantity of the Bone and Mineral learn sequence has been to provide top of the range, up to date studies and in-depth analyses in components the place advancements are, or in all probability will be, of significant curiosity to the Bone and Mineral examine group. The excessive general already demonstrated within the earlier six volumes of this sequence (under course of Dr. William A. Peck) has been maintained. There has een a few excellent growth made inside of a few parts of bone and mineral examine, while in different components a sluggish and slow accumulation of data has led to elevated perception, in order good as together with studies in either parts, the chapters emphasize the advance of latest strategies. The bankruptcy matters lined are as follows

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Additional resources for Bone and Mineral Research. A Regular Survey of Developments in the Field of Bone and Mineral Metabolism, 1st Edition

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Indeed, any change in these calcium fluxes has obvious repercussions on the inter­ nal organization of bone with its primary function for mechanical support, unlike the intestine or kidney which are only concerned with the relationships of calcium with the milieu extérieur. , 1978). Initially proposed by N e u m a n , this kind of calcium dynamics implies mechanisms of self-regulation (Neuman, 1975a) and takes into account the physicochemical properties of the interface between the solution phase and the solid phase at the bone surface.

Considerable evidence indicates a relationship between the quantity of various calcium-binding proteins and the intestinal transport of calcium (Wasserman and Chandler, 1985). Thirdly, extru­ sion across the basolateral membrane. , 1982). , 1966) which directly depends upon diffusible calcium concentration in intestinal lumen and becomes increasingly signifi- 24 cant as the lumenal Ca concentration exceeds the saturating concentration of the active transport system. It may correspond to both paracellular or intercellular transport and transcellular transport via simple diffusion.

30 (a) Nucleation and solid phase growth: In purely chemical systems, there are two major stages ongoing from a homogeneous supersaturated solution to the state of thermodynamic equilibrium (defined by the solubility product) of an s/S system: primary nucleation, and solid mass increment due to crystal growth or secondary nucleation. e. a stable solid phase of the smallest possible size. e. in the presence of compounds other than solute ions, as it is in the biological milieu. These external agents may be considered as catalysts or in­ hibitors depending on whether they facilitate or slow down certain steps of the reac­ tion.

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