Bronchial Hyperresponsiveness by Peter Barnes (auth.), Primarius Dr. Hartmut Zwick (eds.)

By Peter Barnes (auth.), Primarius Dr. Hartmut Zwick (eds.)

The Austrian Pneumological Society held its 33th Workshop on "Clinical respiration body structure" at Graz, November 1 st -3rd, 1990. Bronchial hyperresponsiveness has been recognized approximately so long as bronchial asthma bronchia Ie itself. over the past 20 years whereas exploring the inflammatory nature of bronchial asthma bronchiale now we have realized much approximately measuring and enhancing this phenomenon. as a result functional relevance and as a result of the excessive competence of the authors we are hoping that the lectures and discussions we had at Graz will tell and revel in the reader. i would like to specific my deep gratitude to the entire authors for supplying us with the manuscripts and graphs. eventually i'm in particular thankful to Mrs. H. Weber for her secreterial paintings and to Mrs. magazine. A. Lahrmann-Ramharter for correcting the written model of the speeches and getting ready a manuscript that used to be prepared for the click. Prim. Dr. Hartmut Zwick Contents Barnes P. : mobile and Biochemical points of Airway Hyperresponsiveness. . . . . . . . . . 1 Hargreave F. E. : Airway Hyperresponsiveness and bronchial asthma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Ingram R. H. : Physiologic Correlates of elevated Airway Responsiveness . . . . . . . . . . . . . . . . 36 okay errebijn ok F. : Bronchial Provocation checking out in childrens -Methods and scientific Relevance. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . forty six Tattersfield A. E. : Bronchial Provocation trying out in Adults -Is There medical Relevance. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . sixty four Kummer F. : rules and techniques in bronchial asthma treatment. . . . . . . . . . . . . . . . . . . . . . . . . .

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However, neither of these for asthma as illustrated by the Airway Hyperresponsiveness and Asthma 23 following two points. Figure 4 shows the relationship between PC20 methacholine and the FEV1 NC ratio in a group of smokers with chronic cough and sputum consistent with chronic bronchitis (16). We did not consider that they had asthma. However, you can see that once they had developed chronic airflow limitation with an FEV1 NC ratio of less than about 70%, the PC20 was reduced into the hyperesponsive range.

0'8 7 '( Dose step Fig. 4a: Within - subject reproducibility of PTC02 and FEV1 doseresponse curves. For abbreviations see figure 4. Do we need bronchial provocation testing in children, what are the indications? Possible Indications: * diagnosis of asthma * confirmation of the clinical * * * relevance of atopy marker of disease activity guideline for treatment confirmation of "cure" in an asymptomatic patient research 54 Kerrebijn K. : A diagnosis of asthma in most children and in most adults can easily be made from the history by physical examination and by using for instance exercise induced bronchoconstriction.

E. a constrictor effect of a DI. In fact the worse the obstruction, the lower the VHR. (fig. 1). This is an opposite sign to induced obstruction (2). As the spontaneous obstruction and inflammation abate, the VHR increases toward baseline (3). 5 Log Dose PD 35 SGAW Subsequent Challenge Fig. 2: VHR at baseline in mild asthmatics correlates with responsiveness (expressed as provocative dose for a 35% decrease in specific conductance) to a subsequent methacholine challenge. Redrawn from reference 4.

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